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Article

Localized sphingolipid signaling at presynaptic terminals is regulated by calcium influx and promotes recruitment of priming factors.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 5 Dec 2012

Chan Jason P, Sieburth Derek

Abstract excerpt

Activity-dependent changes in presynaptic function represent a critical mechanism by which synaptic strength is controlled. However, how changes in synaptic activity couple to presynaptic components to control synaptic vesicle release and recycling are poorly understood. Sphingosine kinase (SphK) is a sphingolipid metabolic enzyme whose activity-dependent recruitment to membrane regions within presynaptic...

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Identifiers

PMID: 23223309
DOI: 10.1523/JNEUROSCI.2808-12.2012
PMCID: PMC3545516

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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