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Article

How oncogenic mutations activate human MAP kinase 1 (MEK1): a molecular dynamics simulation study.

Journal of biomolecular structure & dynamics - 1 Aug 2020

Liu Ye, Zhu Jingxuan, Guo Xiaoqing, Huang Tianci, Han Jiarui, Gao Jianjiong, Xu Dong, Han Weiwei

Abstract excerpt

Approximately 30% of all types of human cancers possess a constitutively activated the mitogen-activated protein kinase (MAPK) signaling pathway while MAP kinase 1 (MEK1) is a critical component of this pathway. It has been reported mutations could improve the activity of MEK1 to result in cell proliferation and transformation, which is a known oncogenic event in various cancer types. In this study, eight...

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Identifiers

PMID: 31658877
DOI: 10.1080/07391102.2019.1686065
PMCID: PMC8177546

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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