Article
BRAF-inhibitor Associated MEK Mutations Increase RAF-Dependent and -Independent Enzymatic Activity.
Molecular cancer research : MCR - 1 Oct 2017
Emery Caroline M, Monaco Kelli-Ann, Wang Ping, Balak Marissa, Freeman Alyson, Meltzer Jodi, Delach Scott M, Rakiec Daniel, Ruddy David A, Korn Joshua M, Haling Jacob, Acker Michael G, Caponigro Giordano
Abstract excerpt
Alterations in MEK1/2 occur in cancers, both in the treatment-naïve state and following targeted therapies, most notably BRAF and MEK inhibitors in BRAF-V600E-mutant melanoma and colorectal cancer. Efforts were undertaken to understand the effects of these mutations, based upon protein structural location, and MEK1/2 activity. Two categories of MEK1/2 alterations were evaluated, those associated with either the...
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