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Article

STAT2 is involved in the pathogenesis of psoriasis by promoting CXCL11 and CCL5 production by keratinocytes.

PloS one - 1 Jan 2017

Johansen Claus, Rittig Anne Hald, Mose Maike, Bertelsen Trine, Weimar Isabella, Nielsen Jakob, Andersen Thomas, Rasmussen Tue Kruse, Deleuran Bent, Iversen Lars

Abstract excerpt

The JAK/STAT signaling pathway is suggested to play an important role in the pathogenesis of psoriasis, and recently JAK/STAT inhibitors have shown promising results in psoriasis treatment. The present study aimed to characterize the role of STAT2 in psoriasis. We demonstrated an increased expression of STAT2 and an increased level of phosphorylated/activated STAT2 in lesional compared with nonlesional psoriatic...

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Topics

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Share to Chemokine CCL5
Share to CCL5 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to STAT1 gene

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Share to Genetic Predisposition to Disease

Share to Keratinocytes

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Source

Open in PubMed Open full text

Identifiers

PMID: 28472186
DOI: 10.1371/journal.pone.0176994
PMCID: PMC5417613

Genes

CCL5
CXCL11
STAT2
STAT1
STAT6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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