Article
The skeletal cell-derived molecule sclerostin drives bone marrow adipogenesis.
Journal of cellular physiology - 1 Feb 2018
Fairfield Heather, Falank Carolyne, Harris Elizabeth, Demambro Victoria, McDonald Michelle, Pettitt Jessica A, Mohanty Sindhu T, Croucher Peter, Kramer Ina, Kneissel Michaela, Rosen Clifford J, Reagan Michaela R
Abstract excerpt
The bone marrow niche is a dynamic and complex microenvironment that can both regulate, and be regulated by the bone matrix. Within the bone marrow (BM), mesenchymal stromal cell (MSC) precursors reside in a multi-potent state and retain the capacity to differentiate down osteoblastic, adipogenic, or chondrogenic lineages in response to numerous biochemical cues. These signals can be altered in various...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.