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Article

High Affinity Promotes Internalization of Engineered Antibodies Targeting FGFR1

10 May 2018

Abstract excerpt

Fibroblast growth factor receptor 1 (FGFR1) is a plasma membrane protein that transmits signals from the extracellular environment, regulating cell homeostasis and function. Dysregulation of FGFR1 leads to the development of human cancers and noncancerous diseases. Numerous tumors overproduce FGFR1, making this receptor a perspective target for cancer therapies. Antibody-drug conjugates (ADCs) are highly potent...

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PMID: 29748524
DOI: 10.3390/ijms19051435

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