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Properties of the Adeno-Associated Virus Assembly-Activating Protein

27 Sept 2012

Abstract excerpt

Adeno-associated virus (AAV) capsid assembly requires expression of the assembly-activating protein (AAP) together with capsid proteins VP1, VP2, and VP3. AAP is encoded by an alternative open reading frame of the cap gene. Sequence analysis and site-directed mutagenesis revealed that AAP contains two hydrophobic domains in the N-terminal part of the molecule that are essential for its assembly-promoting...

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PMID: 23015698
DOI: 10.1128/jvi.01675-12

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