Article
Effect of single-dose imipramine on chronic low-back and experimental pain. A randomized controlled trial.
PloS one - 1 Jan 2018
Schliessbach Jürg, Siegenthaler Andreas, Bütikofer Lukas, Limacher Andreas, Juni Peter, Vuilleumier Pascal H, Stamer Ulrike, Arendt-Nielsen Lars, Curatolo Michele
Abstract excerpt
Antidepressants are frequently prescribed as co-analgesics in chronic pain. While their efficacy is well documented for neuropathic pain, the evidence is less clear in musculoskeletal pain conditions. The present study therefore evaluated the effect of the tricyclic antidepressant imipramine on chronic low-back pain in a randomized, double-blinded placebo-controlled design. To explore the mechanisms of action and...
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