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Article

Opioids Diminish the Placebo Antidepressant Response: A Post Hoc Analysis of a Randomized Controlled Ketamine Trial

2024-09-25

Abstract excerpt

<h4>Background</h4> The endogenous opioid system is thought to play a role in the placebo antidepressant response. A recent trial comparing the rapid antidepressant effects of ketamine versus placebo in surgical patients, some of whom were on chronic opioid therapy, revealed a substantial placebo effect. This finding provided an opportunity to test the hypothesis that opioid agonist exposure interacts with placebo...

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Literature Corpus work
3f7aedb1-01ad-5281-ae1b-4355c9b4d9ff
DOI
10.1101/2024.09.24.24314243
Open publication

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Opioids Diminish the Placebo Antidepressant Response: A Post Hoc Analysis of a Randomized Controlled Ketamine TrialDOI 10.1101/2024.09.24.24314243
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