Article
Different impact of calreticulin mutations on human hematopoiesis in myeloproliferative neoplasms.
Oncogene - 1 Jul 2020
El-Khoury Mira, Cabagnols Xénia, Mosca Matthieu, Vertenoeil Gaëlle, Marzac Christophe, Favale Fabrizia, Bluteau Olivier, Lorre Florence, Tisserand Amandine, Rabadan Moraes Graciela, Ugo Valérie, Ianotto Jean-Christophe, Rey Jerôme, Solary Eric, Roy Lydia, Rameau Philippe, Debili Najet, Pasquier Florence, Casadevall Nicole, Marty Caroline, Constantinescu Stefan N, Raslova Hana, Vainchenker William, Plo Isabelle
Abstract excerpt
Mutations of calreticulin (CALRm) define a subtype of myeloproliferative neoplasms (MPN). We studied the biological and genetic features of CALR-mutated essential thrombocythemia and myelofibrosis patients. In most cases, CALRm were found in granulocytes, monocytes, B and NK cells, but also in T cells. However, the type 1 CALRm spreads more easily than the type 2 CALRm in lymphoid cells. The CALRm were also...
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