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Recent insights into the pathogenesis of hyperuricaemia and gout.

Human molecular genetics - 15 Oct 2009

Riches Philip L, Wright Alan F, Ralston Stuart H

Abstract excerpt

Gout is a common rheumatic disease in humans which is characterized by elevation in serum uric acid levels, and deposition of uric acid crystals in the joint. Hyperuricaemia is the primary risk factor for the development of gout and primates have uniquely high levels of serum uric acid due to missense mutations in the uricase gene. Levels of serum uric acid are known to be highly heritable, and mutations in genes...

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Identifiers

PMID: 19808794
DOI: 10.1093/hmg/ddp369

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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