Article
Genome-wide Association Studies of over 30,000 Samples with Bone Mineral Density at Multiple Skeletal Sites and Its Clinical Relevance.
Genomics, proteomics & bioinformatics - 28 Oct 2025
Qian 钱雨 Yu, Xia 夏江威 Jiangwei, Wang 王萍玉 Pingyu, Xie Chao, Lin 蔺红丽 Hong-Li, Li Gloria Hoi-Yee, Yuan 袁丞达 Cheng-Da, Qiu 邱模昌 Mo-Chang, Fang 方义湖 Yi-Hu, Yu 余春富 Chun-Fu, Cai 蔡祥春 Xiang-Chun, Khederzadeh Saber, Zhao 赵翩翩 Pian-Pian, Yang 杨梦圆 Meng-Yuan, Zhong 钟家栋 Jia-Dong, Li 李鑫 Xin, Guan 管彭霖 Peng-Lin, Gu 顾家煊 Jia-Xuan, Gai 盖思睿 Si-Rui, Yi 依香叫 Xiang-Jiao, Tao 陶建国 Jian-Guo, Chen 陈祥 Xiang, Miao 缪毛毛 Mao-Mao, Chen 陈国波 Guo-Bo, Xu 徐林 Lin, Xie 谢书阳 Shu-Yang, Tian 田梗 Geng, Yue 岳华 Hua, Li 李光飞 Guangfei, Xiao 肖文金 Wenjin, Karasik David, Xu 徐又佳 Youjia, Yang 杨柳 Liu, Cheung Ching-Lung, Huang 黄飞 Fei, Zhang 章振林 Zhenlin, Zheng 郑厚峰 Hou-Feng
Abstract excerpt
The ultimate goal of a genome-wide association study (GWAS) is to translate its discoveries into clinical practice. To explore the clinical use of GWAS findings in the bone field, we conducted a GWAS of dual-energy X-ray absorptiometry (DXA)-derived bone mineral density (BMD) traits at 11 skeletal sites, within over 30,000 European individuals from the UK Biobank. A total of 91 unique and independent loci were...
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