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Quantifying the Role of Angiogenesis in Malignant Progression of Gliomas: <i>In Silico</i> Modeling Integrates Imaging and Histology

7 Sept 2011

Abstract excerpt

Gliomas are uniformly fatal forms of primary brain neoplasms that vary from low- to high-grade (glioblastoma). Whereas low-grade gliomas are weakly angiogenic, glioblastomas are among the most angiogenic tumors. Thus, interactions between glioma cells and their tissue microenvironment may play an important role in aggressive tumor formation and progression. To quantitatively explore how tumor cells interact with...

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PMID: 21900399
DOI: 10.1158/0008-5472.can-11-1399

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