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Article

A Quantitative Systems Pharmacology Approach to Infer Pathways Involved in Complex Disease Phenotypes.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2018

Schurdak Mark E, Pei Fen, Lezon Timothy R, Carlisle Diane, Friedlander Robert, Taylor D Lansing, Stern Andrew M

Abstract excerpt

Designing effective therapeutic strategies for complex diseases such as cancer and neurodegeneration that involve tissue context-specific interactions among multiple gene products presents a major challenge for precision medicine. Safe and selective pharmacological modulation of individual molecular entities associated with a disease often fails to provide efficacy in the clinic. Thus, development of optimized...

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PMID: 29736721
DOI: 10.1007/978-1-4939-7847-2_16

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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