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Article

Systemic QSAR and phenotypic virtual screening: chasing butterflies in drug discovery.

Drug discovery today - 1 Jul 2017

Cruz-Monteagudo Maykel, Schürer Stephan, Tejera Eduardo, Pérez-Castillo Yunierkis, Medina-Franco José L, Sánchez-Rodríguez Aminael, Borges Fernanda

Abstract excerpt

Current advances in systems biology suggest a new change of paradigm reinforcing the holistic nature of the drug discovery process. According to the principles of systems biology, a simple drug perturbing a network of targets can trigger complex reactions. Therefore, it is possible to connect initial events with final outcomes and consequently prioritize those events, leading to a desired effect. Here, we...

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PMID: 28274840
DOI: 10.1016/j.drudis.2017.02.004
PMCID: PMC5487293

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