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Article

PM20D1 is a quantitative trait locus associated with Alzheimer's disease.

Nature medicine - 1 May 2018

Sanchez-Mut Jose V, Heyn Holger, Silva Bianca A, Dixsaut Lucie, Garcia-Esparcia Paula, Vidal Enrique, Sayols Sergi, Glauser Liliane, Monteagudo-Sánchez Ana, Perez-Tur Jordi, Ferrer Isidre, Monk David, Schneider Bernard, Esteller Manel, Gräff Johannes

Abstract excerpt

The chances to develop Alzheimer's disease (AD) result from a combination of genetic and non-genetic risk factors 1 , the latter likely being mediated by epigenetic mechanisms 2 . In the past, genome-wide association studies (GWAS) have identified an important number of risk loci associated with AD pathology 3 , but a causal relationship remains difficult to establish. In contrast, locus-specific or...

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PMID: 29736028
DOI: 10.1038/s41591-018-0013-y

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