Article
Genomic Variations Affecting Biological Effects of Statins.
Current drug metabolism - 1 Jan 2016
Bitto Alessandra, Pallio Giovanni, Messina Sonia, Arcoraci Vincenzo, Pizzino Gabriele, Russo Giuseppina T, Pallio Socrate, Squadrito Francesco, Altavilla Domenica
Abstract excerpt
BACKGROUND: Statins are inhibitors of hydroxy-methyl-glutaryl coenzymeA (HMG-CoA) reductase, the rate-limiting enzyme involved in de novo cholesterol synthesis. The patient health profile needs to be taken in account during the interpretation of the variability in the outcome of drug therapy, as well as compliance with prescribed pharmacological treatments, and genetic profile. OBJECTIVE: Several genetic...
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