Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TRAIL receptor upregulation and the implication of KRAS/BRAF mutations in human colon cancer tumors.

International journal of cancer - 1 Nov 2009

Oikonomou Eftychia, Kosmidou Vivian, Katseli Anastasia, Kothonidis Konstantinos, Mourtzoukou Despina, Kontogeorgos George, Andera Ladislav, Zografos Georgios, Pintzas Alexander

Abstract excerpt

TRAIL raises hopes as a promising anti-tumor agent due to its selectivity toward cancer cells. Higher expression of its pro-death receptors TRAIL-R1 (DR4) and TRAIL-R2 (DR5) attenuates higher sensitivity to TRAIL-induced apoptosis, and represents a marker for better cancer prognosis and treatment...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Colonic Neoplasms
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Proto-Oncogene Proteins

Share to Proto-Oncogene Proteins B-raf

Share to Proto-Oncogene Proteins p21(ras)

Share to ras Proteins

Share to Receptors, TNF-Related Apoptosis-Inducing Ligand

Share to Up-Regulation

Source

Identifiers

PMID: 19637313
DOI: 10.1002/ijc.24613

Genes

BRAF
KRAS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19637313-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TRAIL receptor upregulation and the implication of KRAS/BRAF mutations in human colon cancer tumors.PMID 19637313Read ↗

Comprehensive expression analysis of TNF-related apoptosis-inducing ligand and its receptors in colorectal cancer: Correlation with MAPK alterations and clinicopathological associations.Semantic proximity Read ↗

Transformation by oncogenic RAS sensitizes human colon cells to TRAIL-induced apoptosis by up-regulating death receptor 4 and death receptor 5 through a MEK-dependent pathway.Semantic proximity Read ↗

BAY61-3606 potentiates the anti-tumor effects of TRAIL against colon cancer through up-regulating DR4 and down-regulating NF-κB.Semantic proximity Read ↗

Genomic organization and mutation analyses of the DR5/TRAIL receptor 2 gene in colorectal carcinomasSemantic proximity Read ↗

Genetic variants in the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and death receptor (DR4) genes contribute to susceptibility to colorectal cancer in pakistani population.Semantic proximity Read ↗

Downregulation of external death receptor genes FAS and DR5 in colorectal cancer samples positive for human papillomavirus infectionSemantic proximity Read ↗

Microsatellite instability, KRAS mutations and cellular distribution of TRAIL-receptors in early stage colorectal cancer.Semantic proximity Read ↗

CD44 promotes resistance to apoptosis in human colon cancer cellsSemantic proximity Read ↗

The TRAIL decoy receptor TRUNDD (DcR2, TRAIL-R4) is induced by adenovirus-p53 overexpression and can delay TRAIL-, p53-, and KILLER/DR5-dependent colon cancer apoptosis.Semantic proximity Read ↗

RALB GTPase: a critical regulator of DR5 expression and TRAIL sensitivity in KRAS mutant colorectal cancer.Semantic proximity Read ↗

TNFSF10 (TRAIL), a p53 target gene that mediates p53-dependent cell deathSemantic proximity Read ↗

Death receptor 4 variants and colorectal cancer risk.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.