Article
Microsatellite instability, KRAS mutations and cellular distribution of TRAIL-receptors in early stage colorectal cancer.
PloS one - 1 Jan 2012
Kriegl Lydia, Jung Andreas, Horst David, Rizzani Antonia, Jackstadt Rene, Hermeking Heiko, Gallmeier Eike, Gerbes Alexander L, Kirchner Thomas, Göke Burkhard, De Toni Enrico N
Abstract excerpt
BACKGROUND: The fact that the receptors for the TNF-related apoptosis inducing ligand (TRAIL) are almost invariably expressed in colorectal cancer (CRC) represents the rationale for the employment of TRAIL-receptors targeting compounds for the therapy of patients affected by this tumor. Yet, first reports on the use of these bioactive agents provided disappointing results. We therefore hypothesized that loss of...
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