Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Influence of FTDP-17 mutants on circular tau RNAs.

Biochimica et biophysica acta. Molecular basis of disease - 1 Apr 2024

Margvelani Giorgi, Welden Justin R, Maquera Andrea Arizaca, Van Eyk Jennifer E, Murray Christopher, Miranda Sardon Sandra C, Stamm Stefan

Abstract excerpt

At least 53 mutations in the microtubule associated protein tau gene (MAPT) have been identified that cause frontotemporal dementia. 47 of these mutations are localized between exons 7 and 13. They could thus affect the formation of circular RNAs (circRNAs) from the MAPT gene that occurs through backsplicing from exon 12 to either exon 10 or exon 7. We analyzed representative mutants and found that five FTDP-17...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Frontotemporal Dementia
Share to ADAR gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to MAPT gene

Share to Mutation

Share to RNA, Circular

Share to tau Proteins

Source

Identifiers

PMID: 38286213
DOI: 10.1016/j.bbadis.2024.167036

Genes

ADAR
MAPT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Influence of FTDP-17 mutants on circular tau RNAs.PMID 38286213Read ↗

Influence of FTDP-17 mutants on circular Tau RNAsSemantic proximity Read ↗

The human MAPT locus generates circular RNAs.Semantic proximity Read ↗

Circular RNAs from the MAPT and TARDP Genes: Novel Players in Neurodegeneration?Semantic proximity Read ↗

m6A-dependent circular RNA formation mediates tau-induced neurotoxicitySemantic proximity Read ↗

Correction of tau mis-splicing caused by FTDP-17 MAPT mutations by spliceosome-mediated RNA trans-splicing.Semantic proximity Read ↗

Assessing circular RNAs in Alzheimer diseaseSemantic proximity Read ↗

FTDP‐17 mutations N279K and S305N in tau produce increased splicing of exon 10Semantic proximity Read ↗

The RNA encoding the microtubule-associated protein tau has extensive structure that affects its biologySemantic proximity Read ↗

Functional effects of tau gene mutations ΔN296 and N296HSemantic proximity Read ↗

Temporal and Regional Circular RNA profiling in a Tauopathy Mouse Model: Implications for Tau Pathology and NeurodegenerationSemantic proximity Read ↗

Tau exon 10, whose missplicing causes frontotemporal dementia, is regulated by an intricate interplay of cis elements and trans factors.Semantic proximity Read ↗

Brain microRNAs dysregulation: Implication for missplicing and abnormal post-translational modifications of tau protein in Alzheimer’s disease and related tauopathiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.