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Article

Correction of tau mis-splicing caused by FTDP-17 MAPT mutations by spliceosome-mediated RNA trans-splicing.

Human molecular genetics - 1 Sept 2009

Rodriguez-Martin Teresa, Anthony Karen, Garcia-Blanco Mariano A, Mansfield S Gary, Anderton Brian H, Gallo Jean-Marc

Abstract excerpt

Frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17) is caused by mutations in the MAPT gene, encoding the tau protein that accumulates in intraneuronal lesions in a number of neurodegenerative diseases. Several FTDP-17 mutations affect alternative splicing and result in excess exon 10 (E10) inclusion in tau mRNA. RNA reprogramming using spliceosome-mediated RNA trans-splicing (SMaRT) could...

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Identifiers

PMID: 19498037
DOI: 10.1093/hmg/ddp264
PMCID: PMC2722988

Genes

MAPT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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