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Article

Finding MAPT Mutations in Frontotemporal Dementia and Other Tauopathies.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2017

Dobson-Stone Carol, Kwok John B J

Abstract excerpt

Sanger sequencing is a classic technique in molecular genetics to detect single nucleotide DNA variants in genomic DNA. Here we describe the detection of MAPT mutations by polymerase chain reaction amplification of patient genomic DNA followed by bidirectional Sanger sequencing. Exon trapping is a technique whereby genomic DNA covering the exon of interest and flanking intronic sequence is cloned into the intron...

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Source

Identifiers

PMID: 27975259
DOI: 10.1007/978-1-4939-6598-4_19

Genes

MAPT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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