Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Propyl-5-hydroxy-3-methyl-1-phenyl-1H-pyrazole-4-carbodithioate (HMPC): a new bacteriostatic agent against methicillin-resistant Staphylococcus aureus.

Scientific reports - 4 May 2018

Johnston Tatiana, Van Tyne Daria, Chen Roy F, Fawzi Nicolas L, Kwon Bumsup, Kelso Michael J, Gilmore Michael S, Mylonakis Eleftherios

Abstract excerpt

The emergence of Staphylococcus aureus strains resistant to 'last resort' antibiotics compels the development of new antimicrobials against this important human pathogen. We found that propyl 5-hydroxy-3-methyl-1-phenyl-1H-pyrazole-4-carbodithioate (HMPC) shows bacteriostatic activity against S. aureus (MIC = 4 μg/ml) and rescues Caenorhabditis elegans from S. aureus infection. Whole-genome sequencing of S....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dose-Response Relationship, Drug
Share to Genome, Bacterial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Methicillin-Resistant Staphylococcus aureus

Share to Microbial Sensitivity Tests

Share to Molecular Conformation

Share to Molecular Structure

Share to Structure-Activity Relationship

Share to Whole Genome Sequencing

Source

Open in PubMed Open full text

Identifiers

PMID: 29728636
DOI: 10.1038/s41598-018-25571-w
PMCID: PMC5935714

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Propyl-5-hydroxy-3-methyl-1-phenyl-1H-pyrazole-4-carbodithioate (HMPC): a new bacteriostatic agent against methicillin-resistant Staphylococcus aureus.PMID 29728636Read ↗

Genome-Wide Identification of Antimicrobial Intrinsic Resistance Determinants in Staphylococcus aureusSemantic proximity Read ↗

A Review on Five and Six-Membered Heterocyclic Compounds Targeting the Penicillin-Binding Protein 2 (PBP2A) of Methicillin-Resistant Staphylococcus aureus (MRSA)Semantic proximity Read ↗

A MRSA mystery: how PBP4 and cyclic-di-AMP join forces against β-lactam antibiotics.Semantic proximity Read ↗

A Review on Five and Six-Membered Heterocyclic Compounds Targeting the Penicillin-Binding Protein 2 (PBP2A) of Methicillin-Resistant <em>Staphylococcus aureus</em> (MRSA)Semantic proximity Read ↗

Staphylococcus aureus virulence factors identified by using a high-throughput Caenorhabditis elegans-killing model.Semantic proximity Read ↗

Chemoproteomics of an Indole-Based Quinone Epoxide Identifies Druggable Vulnerabilities in Vancomycin-Resistant Staphylococcus aureusSemantic proximity Read ↗

Mechanistic insights and in vivo efficacy of thiosemicarbazones against methicillin-resistant Staphylococcus aureusSemantic proximity Read ↗

Purine and pyrimidine analogues differentially regulate cell wall precursor biosynthesis to control β-lactam susceptibility in methicillin resistant <i>Staphylococcus aureus</i>Semantic proximity Read ↗

Host and antibiotic jointly select for greater virulence in Staphylococcus aureus.Semantic proximity Read ↗

Pyrimidine Analogues as a New Class of Gram-Positive Antibiotics, Mainly Targeting Thymineless-Death Related ProteinsSemantic proximity Read ↗

Elucidation of the Mode of Action of a New Antibacterial Compound Active against Staphylococcus aureus and Pseudomonas aeruginosa.Semantic proximity Read ↗

A copper-dependent compound restores ampicillin sensitivity in multidrug-resistant Staphylococcus aureusSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.