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Article

Staphylococcus aureus virulence factors identified by using a high-throughput Caenorhabditis elegans-killing model.

Infection and immunity - 1 Feb 2005

Begun Jakob, Sifri Costi D, Goldman Samuel, Calderwood Stephen B, Ausubel Frederick M

Abstract excerpt

Staphylococcus aureus is an important human pathogen that is also able to kill the model nematode Caenorhabditis elegans. We constructed a 2,950-member Tn917 transposon insertion library in S. aureus strain NCTC 8325. Twenty-one of these insertions exhibited attenuated C. elegans killing, and of these, 12 contained insertions in different genes or chromosomal locations. Ten of these 12 insertions showed...

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Identifiers

PMID: 15664928
DOI: 10.1128/IAI.73.2.872-877.2005
PMCID: PMC547013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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