Article
The functional polymorphisms on promoter region of matrix metalloproteinase-12, -13 genes may alter the risk of epithelial ovarian carcinoma in Chinese.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society - 1 Jan 2009
Li Yan, Jia Jing-Hui, Kang Shan, Zhang Xiao-Juan, Zhao Jian, Wang Na, Zhou Rong-Miao, Sun Dong-Lan, Duan Ya-Nan, Wang Dong-Jie
Abstract excerpt
BACKGROUNDS AND AIMS: Growing evidences indicate that single nucleotide polymorphisms (SNPs) of matrix metalloproteinases (MMPs) gene promoter may alter MMPs protein expression levels to influence malignant tumors developing and progressing. Our study was to assess the effects of the SNPs in the promoter region of MMP-12 and MMP-13 on the risk of epithelial ovarian carcinoma (EOC) developing and progressing....
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