Article
Somatic Mutations and Clonal Hematopoiesis in Aplastic Anemia
22 Oct 2015
Abstract excerpt
In patients with acquired aplastic anemia, destruction of hematopoietic cells by the immune system leads to pancytopenia.Patients have a response to immunosuppressive therapy, but myelodysplastic syndromes and acute myeloid leukemia develop in about 15% of the patients, usually many months to years after the diagnosis of aplastic anemia. METHODSWe performed next-generation sequencing and array-based karyotyping...
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