Somatic Mutations and Clonal Hematopoiesis in Aplastic Anemia.

doi:10.1056/NEJMoa1414799

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Article

Somatic Mutations and Clonal Hematopoiesis in Aplastic Anemia.

The New England journal of medicine - 2 Jul 2015

Yoshizato Tetsuichi, Dumitriu Bogdan, Hosokawa Kohei, Makishima Hideki, Yoshida Kenichi, Townsley Danielle, Sato-Otsubo Aiko, Sato Yusuke, Liu Delong, Suzuki Hiromichi, Wu Colin O, Shiraishi Yuichi, Clemente Michael J, Kataoka Keisuke, Shiozawa Yusuke, Okuno Yusuke, Chiba Kenichi, Tanaka Hiroko, Nagata Yasunobu, Katagiri Takamasa, Kon Ayana, Sanada Masashi, Scheinberg Phillip, Miyano Satoru, Maciejewski Jaroslaw P, Nakao Shinji, Young Neal S, Ogawa Seishi

Abstract excerpt

BACKGROUND: In patients with acquired aplastic anemia, destruction of hematopoietic cells by the immune system leads to pancytopenia. Patients have a response to immunosuppressive therapy, but myelodysplastic syndromes and acute myeloid leukemia develop in about 15% of the patients, usually many months to years after the diagnosis of aplastic anemia. METHODS: We performed next-generation sequencing and...

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PMID: 26132940
DOI: 10.1056/NEJMoa1414799
PMCID: PMC7478337

Genes

ASXL1
BCOR
BCORL1
PIGA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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