Article
Negative effect of vitamin D on kidney function: a Mendelian randomization study.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 1 Dec 2018
Teumer Alexander, Gambaro Giovanni, Corre Tanguy, Bochud Murielle, Vollenweider Peter, Guessous Idris, Kleber Marcus E, Delgado Graciela E, Pilz Stefan, März Winfried, Barnes Catriona L K, Joshi Peter K, Wilson James F, de Borst Martin H, Navis Gerjan, van der Harst Pim, Heerspink Hiddo J L, Homuth Georg, Endlich Karlhans, Nauck Matthias, Köttgen Anna, Pattaro Cristian, Ferraro Pietro Manuel
Abstract excerpt
Background: The kidney plays a central role in the regulation of vitamin D metabolism. It is not clear, however, whether vitamin D influences kidney function. Previous studies have reported conflicting results, which may have been influenced by reverse causation and residual confounding. We conducted a Mendelian randomization (MR) study to obtain unconfounded estimates of the association between genetically...
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