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Selective Packaging in Murine Coronavirus Promotes Virulence by Limiting Type I Interferon Responses

1 May 2018

Abstract excerpt

ABSTRACT Selective packaging is a mechanism used by multiple virus families to specifically incorporate genomic RNA (gRNA) into virions and exclude other types of RNA. Lineage A betacoronaviruses incorporate a 95-bp stem-loop structure, the packaging signal (PS), into the nsp15 locus of ORF1b that is both necessary and sufficient for the packaging of RNAs. However, unlike other viral PSs, where mutations...

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PMID: 29717007
DOI: 10.1128/mbio.00272-18

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