Article

Identification and targeting of a pan-genotypic influenza A virus RNA structure that mediates packaging and disease

2021-08-21

Abstract excerpt

Currently approved anti-influenza drugs target viral proteins, are subtype limited, and are challenged by rising antiviral resistance. To overcome these limitations, we sought to identify a conserved essential RNA secondary structure within the genomic RNA predicted to have greater constraints on mutation in response to therapeutics targeting this structure. Here, we identified and genetically validated an RNA ste...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ecaf5d92-b754-5faa-98d3-a5b2529642e0
DOI: 10.1101/2021.08.21.457170

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Identification and targeting of a pan-genotypic influenza A virus RNA structure that mediates packaging and diseaseDOI 10.1101/2021.08.21.457170Read

Packaging signals in the 5'-ends of influenza virus PA, PB1, and PB2 genes as potential targets to develop nucleic-acid based antiviral molecules.Semantic proximity Read

Influenza A virus defective viral genomes are inefficiently packaged into virions relative to wild-type genomic RNAsSemantic proximity Read

NSUN2-dependent 5-methylcytosine Modification Regulates Influenza A virus Gene Expression and Genomic PackagingSemantic proximity Read

Mapping of the influenza A virus genome RNA structure and interactions reveals essential elements of viral replicationSemantic proximity Read

Identification of the SARS-CoV-2 genome packaging signal in the nsp12-coding region.Semantic proximity Read

Programmable antivirals targeting critical conserved viral RNA secondary structures from influenza A virus and SARS-CoV-2Semantic proximity Read

Genome-wide mapping of SARS-CoV-2 RNA structures identifies therapeutically-relevant elementsSemantic proximity Read

The highly conserved RNA-binding specificity of nucleocapsid protein facilitates the identification of drugs with broad anti-coronavirus activitySemantic proximity Read

High-throughput Single-Virion DNA-PAINT Reveals Structural Diversity, Cooperativity and Flexibility during Selective Packaging in InfluenzaSemantic proximity Read

The structure of the influenza A virus genomeSemantic proximity Read

Molecular targeting of vulnerable RNA sequences in SARS CoV-2: identifying clinical feasibilitySemantic proximity Read

The influenza A virus genome packaging network — complex, flexible and yet unsolvedSemantic proximity Read