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The structure of<i>Enterococcus faecalis</i>thymidylate synthase provides clues about folate bacterial metabolism

17 Aug 2012

Abstract excerpt

Drug resistance to therapeutic antibiotics poses a challenge to the identification of novel targets and drugs for the treatment of infectious diseases. Infections caused by Enterococcus faecalis are a major health problem. Thymidylate synthase (TS) from E. faecalis is a potential target for antibacterial therapy. The X-ray crystallographic structure of E. faecalis thymidylate synthase (EfTS), which was obtained...

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PMID: 22948925
DOI: 10.1107/s0907444912026236

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