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Article

Structural studies of a hyperthermophilic thymidylate kinase enzyme reveal conformational substates along the reaction coordinate.

The FEBS journal - 1 Aug 2017

Biswas Ansuman, Shukla Arpit, Chaudhary Santosh Kumar, Santhosh Rajendran, Jeyakanthan Jeyaraman, Sekar Kanagaraj

Abstract excerpt

Thymidylate kinase (TMK) is a key enzyme which plays an important role in DNA synthesis. It belongs to the family of nucleoside monophosphate kinases, several of which undergo structure-encoded conformational changes to perform their function. However, the absence of three-dimensional structures for all the different reaction intermediates of a single TMK homolog hinders a clear understanding of its functional...

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PMID: 28627020
DOI: 10.1111/febs.14140

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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