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Article

Biomolecular study of human thymidylate synthase conformer-selective inhibitors: New chemotherapeutic approach.

PloS one - 1 Jan 2018

El-Mesallamy Hala O, El Magdoub Hekmat M, Chapman James M, Hamdy Nadia M, Schaalan Mona F, Hammad Lamiaa N, Berger Sondra H

Abstract excerpt

Thymidylate synthase (TS) is a well-validated target for the therapy of adult cancers. Propane-1,3-diphosphonic acid (PDPA) has significant inhibitory properties against human thymidylate synthase (hTS) relative to mouse TS which is not predicted to adopt an inactive conformer. The current research aims to identify novel, lead inhibitors of hTS and examine the prediction that they bind selectively to hTS enzymes...

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Identifiers

PMID: 29538414
DOI: 10.1371/journal.pone.0193810
PMCID: PMC5851609

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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