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Article

Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states.

The Journal of biological chemistry - 11 Aug 2017

Chen Dan, Jansson Anna, Sim Daniel, Larsson Andreas, Nordlund Pär

Abstract excerpt

Thymidylate synthase (TS) is the sole enzyme responsible for de novo biosynthesis of thymidylate (TMP) and is essential for cell proliferation and survival. Inhibition of human TS (hTS) has been extensively investigated for cancer chemotherapy, but several aspects of its activity and regulation are still uncertain. In this study, we performed comprehensive structural and biophysical studies of hTS using...

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Identifiers

PMID: 28634233
DOI: 10.1074/jbc.M117.787267
PMCID: PMC5555203

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