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Article

Analysis of MSH2 Loss of Heterozygosity, Expression, and IVS10+12G>A Polymorphism in Sporadic Colon Cancer.

Anticancer research - 1 May 2018

Cacev Tamara, Zapletal Emilija, Musani Vesna, Rako Ivana, Loncar Bozo, Aralica Gorana, Kapitanovic Sanja

Abstract excerpt

BACKGROUND: mutS homolog 2 (MSH2) deficiency may be involved in the development of microsatellite instability found in certain sporadic colorectal tumors. In addition to mutations or loss of heterozygosity resulting in complete loss of MSH2 function, polymorphisms affecting MSH2 expression have been also identified. Therefore, the aim of this study was to examine MSH2 status in sporadic colon cancer. MATERIALS...

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Source

Identifiers

PMID: 29715107
DOI: 10.21873/anticanres.12529

Genes

MSH2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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