Article
Defective hMSH2/hMLH1 protein expression is seen infrequently in ulcerative colitis associated colorectal cancers.
Gut - 1 Mar 2000
Cawkwell L, Sutherland F, Murgatroyd H, Jarvis P, Gray S, Cross D, Shepherd N, Day D, Quirke P
Abstract excerpt
BACKGROUND: Ulcerative colitis is associated with an increased risk of colorectal cancer above that of the normal population. The relative risk correlates with the extent and duration of the disease but the genetic basis of ulcerative colitis associated cancer risk is not known. AIMS: To assess the prevalence of microsatellite instability and mismatch repair gene abnormalities in ulcerative colitis associated...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
