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Article

Mutations in MLH1 are more frequent than in MSH2 in sporadic colorectal cancers with microsatellite instability.

Genes, chromosomes & cancer - 1 Jan 1997

Herfarth K K, Kodner I J, Whelan A J, Ivanovich J L, Bracamontes J R, Wells S A, Goodfellow P J

Abstract excerpt

The microsatellite instability that is a feature of tumors in patients with hereditary nonpolyposis colorectal cancer (HNPCC) is a consequence of defective DNA mismatch repair. Mutations in the DNA mismatch repair genes MSH2 and MLH1 may account for up to 90% of HNPCC kindreds. Microsatellite ins...

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Source

Identifiers

PMID: 8993979
DOI: 10.1002/(sici)1098-2264(199701)18:1<42::aid-gcc5>3.0.co;2-1

Genes

MLH1
MSH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-8993979-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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