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Bleomycin: Synthetic and Mechanistic Studies

15 Feb 1999

Abstract excerpt

The subtleties of the structure and function of bleomycin A2 (1), a clinically employed antitumor agent that derives its biological properties through the sequence-selective cleavage of DNA in a process that is dependent on the metal ion and O2, have been unraveled in a stepwise manner. Systematic modifications in the structure of 1 enabled many of the subtle functional roles of the individual subunits and their...

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PMID: 29711767
DOI: 10.1002/(sici)1521-3773(19990215)38:4<448::aid-anie448>3.0.co;2-w

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