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Inhalation of mesenchymal stromal cell‐derived extracellular vesicles activates macrophage polarization through the miR-22-3p/NLRP3/IL-1β pathway, ameliorating lung ischemia‒reperfusion injury

2025-04-24

Abstract excerpt

<title>Abstract</title> <p><bold>Background：</bold>Lung ischemia/reperfusion injury (LIRI) is a primary contributing factor to the occurrence of primary graft dysfunction. Extracellular vesicles derived from mesenchymal stem cells (MSC-EVs) can ameliorate tissue damage and promote recovery in animal models of inflammatory diseases. However, the capacity of MSC-EVs to induce an anti-inflammatory effect in LIRI rem...

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Literature Corpus work
0c1ef5e8-e1e0-50f2-be58-784341f08180
DOI
10.21203/rs.3.rs-6121171/v1
Open publication

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Inhalation of mesenchymal stromal cell‐derived extracellular vesicles activates macrophage polarization through the miR-22-3p/NLRP3/IL-1β pathway, ameliorating lung ischemia‒reperfusion injuryDOI 10.21203/rs.3.rs-6121171/v1
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