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Article

Wharton's Jelly mesenchymal stem cell-derived extracellular vesicles induce liver fibrosis-resolving phenotype in alternatively activated macrophages.

Journal of cellular and molecular medicine - 1 Sept 2024

Torabi Shukoofeh, Zarrabi Morteza, Shekari Faezeh, Poorkazem Hedie, Lotfinia Majid, Bencina Stefan, Gramignoli Roberto, Hassan Moustapha, Najimi Mustapha, Vosough Massoud

Abstract excerpt

The potential of extracellular vesicles (EVs) isolated from mesenchymal stromal cells in guiding macrophages toward anti-inflammatory immunophenotypes, has been reported in several studies. In our study, we provided experimental evidence of a distinctive effect played by Wharton Jelly mesenchymal stromal cell-derived EVs (WJ-EVs) on human macrophages. We particularly analyzed their anti-inflammatory effects on...

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Share to Extracellular Vesicles
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39288445
DOI: 10.1111/jcmm.18507
PMCID: PMC11407755

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