Article
Ancestral State Reconstruction of the Apoptosis Machinery in the Common Ancestor of Eukaryotes.
G3 (Bethesda, Md.) - 31 May 2018
Klim Joanna, Gładki Arkadiusz, Kucharczyk Roza, Zielenkiewicz Urszula, Kaczanowski Szymon
Abstract excerpt
Apoptotic cell death is a type of eukaryotic cell death. In animals, it regulates development, is involved in cancer suppression, and causes cell death during pathological aging of neuronal cells in neurodegenerative diseases such as Alzheimer's. Mitochondrial apoptotic-like cell death, a form of primordial apoptosis, also occurs in unicellular organisms. Here, we ask the question why the apoptosis machinery has...
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