Caspases. Regulating Death Since the Origin of Life

Abstract excerpt

Programmed cell death (PCD) is the genetically controlled suicide of cells. The tight regulation of this program is essential to ensure that it is only activated in the required cells at the proper moment. Deregulation of apoptosis, the main form of PCD in animals, is associated with diseases such as cancer, autoimmune diseases, and neurodegenerative disorders (Shi, 2002). In plants, deregulation of PCD is often...

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