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Cell death proteins: An evolutionary role in cellular adaptation before the advent of apoptosis

14 Aug 2013

Abstract excerpt

Programmed cell death (PCD) or apoptosis is a broadly conserved phenomenon in metazoans, whereby activation of canonical signal pathways induces an ordered dismantling and death of a cell. Paradoxically, the constituent proteins and pathways of PCD (most notably the metacaspase/caspase protease mediated signal pathways) have been demonstrated to retain non-death functions across all phyla including yeast,...

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PMID: 23943356
DOI: 10.1002/bies.201300052

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