Article
Striatal dopamine release and impaired reinforcement learning in adults with 22q11.2 deletion syndrome.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 Jun 2018
van Duin Esther D A, Kasanova Zuzana, Hernaus Dennis, Ceccarini Jenny, Heinzel Alexander, Mottaghy Felix, Mohammadkhani-Shali Siamak, Winz Oliver, Frank Michael, Beck Merrit C H, Booij Jan, Myin-Germeys Inez, van Amelsvoort Thérèse
Abstract excerpt
22q11.2 deletion syndrome (22q11DS) is a genetic disorder caused by a microdeletion on chromosome 22q11.2 and associated with an increased risk for developing psychosis. The catechol-O-methyltransferase (COMT) gene is located in the deleted region and involved in dopamine (DA) breakdown. Impaired reinforcement learning (RL) is a recurrent feature in psychosis and thought to be related to abnormal striatal DA...
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