Article
Comparison of whole-exome sequencing of matched fresh and formalin fixed paraffin embedded melanoma tumours: implications for clinical decision making.
Pathology - 1 Apr 2016
De Paoli-Iseppi Ricardo, Johansson Peter A, Menzies Alexander M, Dias Kerith-Rae, Pupo Gulietta M, Kakavand Hojabr, Wilmott James S, Mann Graham J, Hayward Nicholas K, Dinger Marcel E, Long Georgina V, Scolyer Richard A
Abstract excerpt
The identification of recurrent driver mutations by whole-exome sequencing (WES) of fresh-frozen human cancers and the subsequent development of novel targeted therapies have recently transformed the treatment of many cancers including melanoma. In routine clinical practice, fresh-frozen tissue is rarely available and mutation testing usually needs to be carried out on archival formalin fixed, paraffin embedded...
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