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Article

A Pilot Study for the Feasibility of Exome-Sequencing in Circulating Tumor Cells Versus Single Metastatic Biopsies in Breast Cancer.

International journal of molecular sciences - 8 Jul 2020

Kaur Pushpinder, Campo Daniel, Porras Tania B, Ring Alexander, Lu Janice, Chairez Yvonne, Su Yunyun, Kang Irene, Lang Julie E

Abstract excerpt

The comparison of the landscape of somatic alterations in circulating tumor cells (CTCs) versus metastases is challenging. Here, we comprehensively characterized the somatic landscape in bulk (amplified and non-amplified), spike-in breast cancer cells, CTCs, and metastases from breast cancer patients using whole-exome sequencing (WES). We determined the level of genomic concordance for somatic nucleotide variants...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32650480
DOI: 10.3390/ijms21144826
PMCID: PMC7402350

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