Article
Behavioral and neurochemical dysfunction in the circling (ci) rat: a novel genetic animal model of a movement disorder.
Neuroscience - 1 Oct 1996
Löscher W, Richter A, Nikkhah G, Rosenthal C, Ebert U, Hedrich H J
Abstract excerpt
One of the crucial breakthroughs in research on parkinsonism was the observation of circling behaviour in rodents after unilateral intranigral injection of 6-hydroxydopamine. This Ungerstedt model remains one of the basic animal models of Parkinson's disease. We report here the first mutant rat s...
Topics
- Amphetamine
- Animals
- Antiparkinson Agents
- Apomorphine
- Behavior, Animal
- Brain Chemistry
- Central Nervous System Stimulants
- Dizocilpine Maleate
- Dopamine
- Excitatory Amino Acid Agonists
- Female
- Forelimb
- Male
- Motor Activity
- Motor Skills
- Movement Disorders
- Mutation
- Rats