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Article

Behavioral and neurochemical dysfunction in the circling (ci) rat: a novel genetic animal model of a movement disorder.

Neuroscience - 1 Oct 1996

Löscher W, Richter A, Nikkhah G, Rosenthal C, Ebert U, Hedrich H J

Abstract excerpt

One of the crucial breakthroughs in research on parkinsonism was the observation of circling behaviour in rodents after unilateral intranigral injection of 6-hydroxydopamine. This Ungerstedt model remains one of the basic animal models of Parkinson's disease. We report here the first mutant rat strain with abnormal circling behaviour and several other features reminiscent of the Ungerstedt Parkinson model. The...

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PMID: 8895881
DOI: 10.1016/0306-4522(96)00248-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Behavioral and neurochemical dysfunction in the circling (ci) rat: a novel genetic animal model of a movement disorder.PMID 8895881Read ↗

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