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Article

Association of Raynaud's phenomenon with a polymorphism in the NOS1 gene.

PloS one - 1 Jan 2018

Munir Sabrina, Freidin Maxim B, Brain Susan, Williams Frances M K

Abstract excerpt

BACKGROUND: Raynaud's phenomenon (RP) describes the phenomenon of recurrent vasospasm of digital arteries, associated with skin colour changes: pallor, cyanosis and erythema. Twin studies have indicated a genetic predisposition for RP; however, the precise aetiology of RP remains unknown. It is thought that genetic variation in temperature-responsive or vasospastic genes might underlie RP so performed a candidate...

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Source

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Identifiers

PMID: 29698501
DOI: 10.1371/journal.pone.0196279
PMCID: PMC5919461

Genes

NOS1
CALCB
CALCA
TRPA1
TRPM8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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