A case-control study of candidate vasoactive mediator genes in primary Raynaud's phenomenon.

doi:10.1093/rheumatology/38.11.1094

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A case-control study of candidate vasoactive mediator genes in primary Raynaud's phenomenon.

Rheumatology (Oxford, England) - 1 Nov 1999

Smyth A E, Hughes A E, Bruce I N, Bell A L

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OBJECTIVES: To elucidate possible genetic factors involved in the pathogenesis of primary Raynaud's phenomenon (RP) and to determine the demographic features. METHODS: The allele frequencies of known polymorphisms in four vasoactive candidate genes, eNOS, BKRG, ET-1 and the ETA receptor genes, were compared in a phenotypically homogeneous group of patients with primary RP and a normal control population. RESULTS:...

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A case-control study of candidate vasoactive mediator genes in primary Raynaud's phenomenon.

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