Article
SNP/haplotype associations of CCR2 and CCR5 genes with severity of chagasic cardiomyopathy.
Human immunology - 1 Dec 2014
Machuca Mayra Alejandra, Suárez Edwin Uriel, Echeverría Luis Eduardo, Martín Javier, González Clara Isabel
Abstract excerpt
BACKGROUND: Chronic inflammation plays a major role in the tissue injury seen in the chronic chagasic cardiomyopathy. The CCR2 and CCR5 chemokine receptors are involved with the type of cellular infiltrate present in cardiac tissue and CCR5-gene variants were previously associated with this pathology. METHODS AND RESULTS: This is a replication study in an independent cohort with larger sample size. Nine SNPs of...
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